Serum Leptin and Adiponectin Levels and the Coronary Artery Disease in Patients Undergoing Angiography
Authors
-
Ahmad Reza Bagheri
Department of Cardiology, Qom University of Medical Sciences, Qom, Iran.
https://orcid.org/0000-0002-3759-3511
-
Sedigheh Molaei
Student Research Committee, Qom University of Medical Sciences, Qom, Iran.
https://orcid.org/0000-0002-2477-4225
-
Negar Parviz
Neurosciences Research Center, Qom University of Medical Sciences, Qom, Iran.
https://orcid.org/0000-0001-5082-5316
-
Sadegh Yoosefee
Spiritual Health Research Center, Qom University of Medical Sciences, Qom, Iran.
https://orcid.org/0000-0001-9033-9144
DOI:
https://doi.org/10.22100/sjms.v11i2.1212Keywords:
Leptin, Adiponectin, Leptin/Adiponectin ratio, Coronary artery diseaseAbstract
Background: It has been shown the adipokines, including leptin and adiponectin, have a prominent role in the pathogenesis of coronary artery disease (CAD). Nevertheless, conflicting results have been reported. The aim of the current study was to clarify the association of the leptin, adiponectin, and leptin to adiponectin (L/R) ratio with the severity of coronary atherosclerosis in an Iranian patient with CAD undergoing angiography.
Methods: We evaluated leptin, adiponectin, and leptin/ adiponectin (L/A) ratio as predictors of CAD severity in 179 Iranian patients based on the severity of CAD. Participants were divided into four groups. Statistical analyses were performed using SPSS22 software, and significance was defined as P-value<0.05.
Results: Among participants 78 persons (43.6%) were female. The mean (SD) age, BMI, serum leptin, adiponectin levels were 58.99 (10.07), 28.26 (4.11), and 1.55 (0.40), 8.48 (2.40) respectively. The angiographic evaluations of patients showed that 52 (29%) of participants had only one involved vessel, 29 (16%) had two involved vessels, 26 (15%) had three involved vessels, and 72 (40%) had mild vessel involved.
Conclusions: Our analysis found no significant link between L/A ratio and CAD severity.
References
Arita Y, Kihara S, Ouchi N, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 2002;105(24):2893-2898. doi: /10.1161/01.CIR.0000018622.84402.FF
Tsao CW, Aday AW, Almarzooq ZI, et al. Heart disease and stroke statistics-2023 update: a report from the American Heart Association. Circulation 2023;147(8):e93-e621. doi: /10.1161/CIR.0000000000001137
Bickel C, Schnabel RB, Zeller T, et al. Predictors of leptin concentration and association with cardiovascular risk in patients with coronary artery disease: Results from the Athero Gene study. Biomarkers 2017;22(3-4):210-218. doi: /10.3109/1354750X.2015.1130745
Mora C, Pintado C, Rubio B, et al. Central leptin regulates heart lipid content by selectively increasing PPAR β/δ expression. Journal of Endocrinology 2018;236(1):43-56. doi: /10.1530/JOE-17-0554
Iqbal J, Mascareno E, Chua S, Hussain MM. Leptin-mediated differential regulation of microsomal triglyceride transfer protein in the intestine and liver affects plasma lipids. Journal of Biological Chemistry 2020;295(13):4101-4113. doi: /10.1074/jbc.RA119.011881
Lancha A, Frühbeck G, Gómez-Ambrosi J. Peripheral signalling involved in energy homeostasis control. Nutrition research reviews 2012;25(2):223-248. doi: /10.1017/S0954422412000145
Frühbeck G. Intracellular signalling pathways activated by leptin. Biochemical Journal 2006;393(1):7-20. doi: /10.1042/BJ20051578
Blüher M, Mantzoros CS. From leptin to other adipokines in health and disease: facts and expectations at the beginning of the 21st century. Metabolism 2015;64(1):131-145. doi: /10.1016/j.metabol.2014.10.016
Gómez-Ambrosi J, Salvador J, Silva C, et al. Increased cardiovascular risk markers in obesity are associated with body adiposity: role of leptin. 2006; doi: /10.1160/TH06-02-0079
Dubey L, Zeng H-S, Wang H-J, Liu R-Y. Potential role of adipocytokine leptin in acute coronary syndrome. Asian cardiovascular and thoracic annals 2008;16(2):124-128. doi: /10.1177/021849230801600209
Wolk R, Berger P, Lennon RJ, Brilakis ES, Johnson BD, Somers VK. Plasma leptin and prognosis in patients with established coronary atherosclerosis. Journal of the American College of Cardiology 2004;44(9):1819-1824. doi: /10.1016/j.jacc.2004.07.050
Jun JY, Ma Z, Pyla R, Segar L. Leptin treatment inhibits the progression of atherosclerosis by attenuating hypercholesterolemia in type 1 diabetic Ins2+/Akita: apoE−/− mice. Atherosclerosis 2012;225(2):341-347. doi: /10.1016/j.atherosclerosis.2012.10.031
Stern JH, Rutkowski JM, Scherer PE. Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell metabolism 2016;23(5):770-784. doi: /10.1016/j.cmet.2016.04.011
Hara T, Fujiwara H, Shoji T, Mimura T, Nakao H, Fujimoto S. Decreased plasma adiponectin levels in young obese males. Journal of atherosclerosis and thrombosis 2003;10(4):234-238. doi: /10.5551/jat.10.234
Teoh H, Strauss MH, Szmitko PE, Verma S. Adiponectin and myocardial infarction: a paradox or a paradigm? : Oxford University Press; 2006. doi: /10.1093/eurheartj/ehl248
Krysiak R, Sierant M, Marek B, Bienek R, Okopień B. The effect of angiotensin-converting enzyme inhibitors on plasma adipokine levels in normotensive patients with coronary artery disease. Endokrynologia Polska 2010;61(3):280-286.
Yokoyama H, Saito S, Daitoku K, et al. Effects of pravastatin and rosuvastatin on the generation of adiponectin in the visceral adipose tissue in patients with coronary artery disease. Fundamental & clinical pharmacology 2011;25(3):378-387. doi: /10.1111/j.1472-8206.2010.00847.x
Lim H, Tayebjee M, Tan K, Patel J, Macfadyen R, Lip G. Serum adiponectin in coronary heart disease: ethnic differences and relation to coronary artery disease severity. Heart 2005;91(12):1605-1606. doi: /10.1136/hrt.2004.047803
Pérez-Pérez A, Sánchez-Jiménez F, Vilariño-García T, Sánchez-Margalet V. Role of leptin in inflammation and vice versa. International journal of molecular sciences 2020;21(16):5887. doi: /10.3390/ijms21165887
Masquio DC, de Piano A, Sanches PL, et al. The effect of weight loss magnitude on pro‐/anti‐inflammatory adipokines and carotid intima-media thickness in obese adolescents engaged in interdisciplinary weight loss therapy. Clinical Endocrinology 2013;79(1):55-64. doi: /10.1111/j.1365-2265.2012.04504.x
Rahmani A, Toloueitabar Y, Mohsenzadeh Y, Hemmati R, Sayehmiri K, Asadollahi K. Association between plasma leptin/adiponectin ratios with the extent and severity of coronary artery disease. BMC cardiovascular disorders 2020;20(1):1-9. doi: /10.1186/s12872-020-01723-7
Katsiki N, Mikhailidis DP, Banach M. Leptin, cardiovascular diseases and type 2 diabetes mellitus. Acta Pharmacologica Sinica 2018;39(7):1176-1188. doi: /10.1038/aps.2018.40
Chai S-B, Sun F, Nie X-L, Wang J. Leptin and coronary heart disease: a systematic review and meta-analysis. Atherosclerosis 2014;233(1):3-10. doi: /10.1016/j.atherosclerosis.2013.11.069
Wallace AM, McMahon AD, Packard CJ, et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation 2001;104(25):3052-3056. doi: /10.1161/hc5001.101061
Ley SH, Harris SB, Connelly PW, et al. Adipokines and incident type 2 diabetes in an Aboriginal Canadian population: the Sandy Lake Health and Diabetes Project. Diabetes care 2008;31(7):1410-1415. doi: /10.2337/dc08-0036
Shimada K, Miyazaki T, Daida H. Adiponectin and atherosclerotic disease. Clinica chimica acta 2004;344(1-2):1-12. doi: /10.1016/j.cccn.2004.02.020
Shioji K, Moriwaki S, Takeuchi Y, Uegaito T, Mutsuo S, Matsuda M. Relationship of serum adiponectin level to adverse cardiovascular events in patients who undergo percutaneous coronary intervention. Circulation Journal 2007;71(5):675-680. doi: /10.1253/circj.71.675
Yeung SLA, Schooling CM. Adiponectin and coronary artery disease risk: A bi-directional Mendelian randomization study. International journal of cardiology 2018;268:222-226. doi: /10.1016/j.ijcard.2018.03.132
Welsh P, Murray HM, Buckley BM, et al. Leptin predicts diabetes but not cardiovascular disease: results from a large prospective study in an elderly population. Diabetes care 2009;32(2):308-310. doi: /10.2337/dc08-1458
Brennan A, Li T, Kelesidis I, Gavrila A, Hu F, Mantzoros C. Circulating leptin levels are not associated with cardiovascular morbidity and mortality in women with diabetes: a prospective cohort study. Diabetologia 2007;50(6):1178-1185. doi: /10.1007/s00125-007-0635-y
Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart disease and stroke statistics-2017 update: a report from the American Heart Association. circulation 2017;135(10):e146-e603. doi: /10.1161/CIR.0000000000000491
North BJ, Sinclair DA. The intersection between aging and cardiovascular disease. Circulation research 2012;110(8):1097-1108. doi: /10.1161/CIRCRESAHA.111.246876
Paneni F, Diaz Cañestro C, Libby P, Lüscher TF, Camici GG. The aging cardiovascular system: understanding it at the cellular and clinical levels. Journal of the American College of Cardiology 2017;69(15):1952-1967. doi: /10.1016/j.jacc.2017.01.064
Couillard C, Lamarche B, Mauriège P, et al. Leptinemia is not a risk factor for ischemic heart disease in men: prospective results from the Quebec Cardiovascular Study. Diabetes care 1998;21(5):782-786. doi: /10.2337/diacare.21.5.782
Sattar N, Wannamethee G, Sarwar N, et al. Leptin and coronary heart disease: prospective study and systematic review. Journal of the American College of Cardiology 2009;53(2):167-175. doi: /10.1016/j.jacc.2008.09.035
Lawlor DA, Smith GD, Kelly A, Sattar N, Ebrahim S. Leptin and coronary heart disease risk: prospective case control study of British women. Obesity 2007;15(7):1694-1701. doi: /10.1038/oby.2007.202
Zhang Y, Huang X, Sun K, et al. The potential role of serum IGF-1 and leptin as biomarkers: towards screening for and diagnosing postmenopausal osteoporosis. Journal of Inflammation Research 2022:533-543. doi: /10.2147/JIR.S344009
Sook Lee E, Park S-s, Kim E, et al. Association between adiponectin levels and coronary heart disease and mortality: a systematic review and meta-analysis. International journal of epidemiology 2013;42(4):1029-1039. doi: /10.1093/ije/dyt087
Tragante V, Asselbergs FW. Mendelian randomization: A powerful method to determine causality of biomarkers in diseases. International journal of cardiology 2018;268:227-228. doi: /10.1016/j.ijcard.2018.05.049
Published
Issue
Section
License
The Copyright Form should be downloaded and signed by corresponding author in the fourth step "upload supplementary files" during submission process.
After acceptance, copyright form should be downloaded and signed by all authors one by one ( "summery --> supp. file" part and click on "add a supplementary file" link).
