International Journal of Health Studies2423-65948220211025 The Effectiveness of Prevention and Relationship Enhancement Program (PREP) on Marital Burnout in Married Women 3640 10.22100/ijhs.v8i2.919 EN Niloofar Mikaeili Department of Psychology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. Seifollah Aghajani Department of Psychology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. Narges Habibi Department of Psychology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran. Elham Fathi Department of Counselling, Faculty of Humanities, Hazrat-e Masoumeh University, Qom, Iran. Abolfazl Hatami Varzaneh Department of Counselling, Faculty of Humanities, Hazrat-e Masoumeh University, Qom, Iran. 2021101 20211025 20211004 Background: This study aimed to investigate the effectiveness of the prevention and relationship enhancement program (PREP) on marital burnout in married women. Methods: Thirty married women were selected and randomly replaced in experimental (n=15) and control (n=15) groups. The quasi-experimental research method was conducted in the pretest-posttest control group design to examine the effectiveness of the PREP on marital burnout in married women. The sessions of the PREP were implemented for the experimental group during 8 sessions of 90 minutes, one session per week, and no educational intervention was performed for the control group. Multivariate analysis of covariance was used as a statistical method. Results: The results showed that there was a significant difference between the control and experimental groups in psychological and emotional aspects of marital burnout(Pvalue≤0.02). Our results also showed that the total burnout score was significantly different from pre-test to post-test in the experimental group (Pvalue≤0.01). Conclusions: It can be implied from the results of our study that PREP can have different implications in Iranian culture. Keywords: Prevention and Relationship Enhancement Program (PREP), Marital Burnout, Married Women.