International Journal of Health Studies2423-65947220210425 Healthcare Workers Coronavirus (COVID-19) Infection during an Early Phase of the Pandemic: A Systematic Review and Meta-Analysis 2430 10.22100/ijhs.v7i2.857EN Mostafa Dianati Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran. Mozhgan Fardid Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran. Maryam Khoramrooz Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran. Fariba Zare Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran. Alireza Azizi Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran. Seyed Mohammad Mirrezaie Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran. Farideh Sadeghian Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran. Shayesteh Jahanfar School of Health Sciences-MPH Program, Health Professions Building 2212, Central Michigan University, USA. 20210330 20210419 20210411 Background: Infection and death of health care workers (HCWs) with COVID-19 is an important health problem and will lead to inadequate care of patients, causes more damage and more spread of this pandemic. This study aimed to combine data on COVID-19 infection among HCWs through a systematic review and meta-analysis study. Methods: We searched PubMed via MEDLINE, the SCOPUS, and Web of Science (ISI) to identify the studies on the prevalence of HCWs infection among COVID-19 patients. We used an eight-item checklist critically appraised to assess the quality of publications on the COVID-19 infection among HCWs. Random-effect models and meta-regression were used for the meta-analysis of the results. Results: Overall, 98 articles were retrieved from the databases, of which, seven met the eligibility criteria published between December 2019 to March 2020. The total sample size of the included studies contained 72677 COVID-19 confirmed cases, of which 3131 were HCWs. The pooled COVID-19 infection prevalence among HCWs was 4% (95% CI: 3% to 5%). Conclusions: According to the results, COVID-19 infection in HCWs was 4% of all cases in the early phase of the pandemic. So HCWs need special care including regular screening and appropriate, adequate, and standard personal protective equipment (PPE). Keywords: Novel Coronavirus, COVID-19, Health Care Workers, Medical Staff.