Shahroud University of Medical siences Shahroud Journal of Medical Sciences 2423-6594 11 2 2025 07 18 The Relationship Between eHealth Literacy and Stress, Anxiety, and Depression Among University Students 16 22 eng Faeze Sobhanifar MSc of Psychiatric Nursing, Department of Nursing, University Social welfare and Rehabilitation Sciences, Tehran, Iran; 2 PhD Student in Nursing, Department of Nursing, School of Nursing and Midwifery, Guilan University of Medical Sciences, Rasht, Iran.. faezesobhanifar@gmail.com Reza Ahmadi Jirandeh MSc of Psychiatric Nursing, Department of Nursing, University Social welfare and Rehabilitation Sciences, Tehran, Iran.. rezaahmadi1378151@gmail.com Sajad Javanbakht MSc of Psychiatric Nursing, Department of Nursing, University Social welfare and Rehabilitation Sciences, Tehran, Iran.. sa.javan3@gmail.com Mohsen Vahedi Assistant Professor, Department of Biostatistics and Epidemiology, Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.. mohsenvahedi540@gmail.com Abolfazl Rahgoi Instructor, Department of Nursing, University Social welfare and Rehabilitation Sciences, Tehran, Iran.. ab.rahgoi@uswr.ac.ir 2025 05 22 2025 07 04 Background: The growing use of the internet and low eHealth literacy may contribute to increased mental health issues such as stress, anxiety, and depression among university students, who are a key group in society. This study explored the relationship between eHealth literacy and stress, anxiety, and depression among undergraduate students at the University of Social Welfare and Rehabilitation Sciences. Methods: This descriptive correlational study was conducted with the participation of 300 undergraduate students from the University of Social Welfare and Rehabilitation Sciences, Tehran, in 2024, using convenience sampling. The research instrument was an electronic questionnaire consisting of a demographic checklist, the Norman eHealth Literacy Scale, and the Depression, Anxiety, and Stress Scale (DASS). The results were analyzed using SPSS version 25 and statistical tests including Levene’s test, independent t-test, ANOVA, Welch’s ANOVA, Pearson’s correlation coefficient, and multiple regression. Results: The mean and standard deviation of eHealth literacy were 31.15±3.60, indicating a favorable level. The mean and standard deviation of stress, anxiety, and depression among undergraduate students were 13.43±9.01, 13.58±8.83, and 15.15±9.01, respectively, indicating normal, moderate, and moderate levels, respectively. Pearson’s correlation coefficient test revealed a significant inverse correlation between eHealth literacy and stress (r=-0.402), anxiety (r=-0.351), and depression (r=-0.353) (P-value<0.001). Conclusions: E-Health literacy is associated with and can predict levels of stress, anxiety, and depression. Therefore, it is necessary and essential to develop educational programs, including media literacy and eHealth literacy training, which can have a positive impact on mental health.