Shahroud University of Medical siences International Journal of Health Studies 2423-6594 2024 06 08 Oral Manifestations in Patients with Rheumatoid Arthritis in the Rheumatology Clinic in Southeast Iran 10.22100/ijhs.v10i2.1115 eng Shahin Nosratzehi Assistant Professor of Endocrinology & Metabolism, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. . shnosratzehi123@gmail.com Hamid Kalalian-moghaddam Associate Professor, Department of Physiology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran. . h.kalalian@shmu.ac.ir Tahereh Nosratzehi Associate Professor, Department of Oral and Maxillofacial Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. . taherehnosratzahi@yahoo.com Abolfazl Payandeh Associate Professor, Department of Biostatistics and Epidemiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. . payandeh@zaums.ac.ir Mahin Nosratzehi Assistant Professor of Rheumatology, Department of Internal Medicine, School of Medicine, Zahedan University of Medical Science, Zahedan, Iran. . Mahnosratzehi@gmail.com Mohammadreza Pournamdari School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran. . Pournamdarimr@yahoo.com 2024 05 25 2024 05 27 Background: Rheumatoid Arthritis (RA) as an autoimmune disease involving joints can cause oral manifestations in patients. This study aimed to investigate the prevalence of oral manifestations in patients with RA referred to the rheumatology clinic of Zahedan University of Medical Sciences in 2022. Methods: The present study was a descriptive cross-sectional observational study and included all patients with RA who were referred to Imam Ali Hospital, Zahedan Rheumatology Clinic for treatment in 2022. The method was non-probability convenience sampling and the obtained information was recorded in the information form made by the researcher. After collecting the data, the raw data was entered into the statistical software SPSS version 24 and analyzed using t-test and Fisher's exact test. Results: According to the findings of the present study, there is no significant difference between the frequency of oral manifestations of 55 patients with RA referred to the rheumatology clinic of Zahedan University of Medical Sciences in the two groups of men and women (Pvalue=0.50). Also, the average age of people in the two groups of patients with oral manifestations and patients without oral manifestations is not statistically significant (Pvalue=0.50). The frequency distribution of oral manifestations of patients with RA showed that xerostomia was the most frequent among oral manifestations. Conclusions: It seems that the frequency of oral mucosal lesions in people with RA is high and their importance can be emphasized as a possible complication of the disease.